Hmm... this is giving me 'Nowhere Man' vibes from the '90s. Photographer guy’s life gets erased? It's super underrated but has a cult following. See if that’s the one!

Honestly, the show you're describing sounds like a myth. Like someone took a bit of Jason Bourne, a dash of 'The X-Files,' and voila! But hey, if it’s real, color me intrigued.

Lol, you literally described half the shows from the 2000s. Gonna need more to go on than amnesia and 'BIG stuff'.

OMG, are you thinking of ‘John Doe’? The dude wakes up naked on an island and has to figure out his life. It was canceled after one season but soooo good.

I have no idea but this sounds amazing! Gonna follow this thread for the answer bc it sounds like my kinda show lol.

This totally sounds like 'Blindspot'. The main character isn't a guy, but a woman who wakes up in Times Square with no memory and mysterious tattoos all over her body, and it's definitely tied to a larger conspiracy. It’s a perfect fit other than the gender switch and the motel room detail. Check it out!

Sounds kinda like 'Kyle XY,' but that wasn't really about a government conspiracy... I think 'Traveler' is closer to what you're describing though, guy wakes up and he’s wrapped up in some serious shady stuff. Not sure it's the one but hope this helps!