Yes, this is something exciting.
So, I finally found out that the whole series was 2D and the titular Pixls (Scandrew and Charlotte) were 3D rendered using Maya and would be later be inspired by the Pixls of Super Paper Mario due to their appearance and cuteness.
Also, I found out that the series premiered on September 16, 2005, lasted 2 seasons with 52 episodes, and ended with an hour-long goodbye special on May 13, 2007.
I also managed to find a forum and there was an user who said that this show aired during the Dick and Dom in Da Bungalow program on CBBC alongside other kids show as well, and had to move to CITV after the program ended in 2006.
Lastly, I found a schedule of ABS-CBN from 2016 and they had this show in Tagalog.
Wow, I've been following Scandrew and Charlotte for years! I can confirm the 3D rendering using Maya is spot on. Interesting to note the move from CBBC with Dick and Dom to CITV, not many shows survive that kind of network shuffle. Any chance you've come across the goodbye special? It's like the holy grail of the series!